recently posted an article on LinkedIn about Vitamin C and how it affects
certain immune cells and stem cells in the body. Most of the articles I have
posted on LinkedIn are aimed more towards scientists and physicians. They are
fairly technical and my writeups have more of a technical blush than my blogs.
I have included this article at the end of this blog. My blogs also contain a
good bit of science but are not as intense.
thought this was an interesting article for everyone. The article discusses the
aspects as to how Vitamin C boosts our immune system and helps control actions
of our DNA. How Vitamin C works is a topic most of us think we know about but when
asked how Vitamin C really works the discussion becomes silent. The article discusses
the use of Vitamin C in increasing the health of a certain type of immune cell
in the body and how Vitamin C ultimately effects our DNA function by
controlling some of our genes. The diagram below shows the different immune
cells we have. All of these cells have their place and at times they can save
our life such as in the face of an infection.
cell we are most interested in this case is called a Regulatory T-cell or as it
is more commonly called a T-reg cell. T-reg cells are of the upmost importance
in that they help prevent autoimmune diseases. Regulatory T cells police the immune system and keep it in
check. Just as important,
T-regs promote tissue repair and
regeneration by modulating inflammation. Extra T-reg cells will do nothing but
improve results for a wide variety of conditions from the treatment of
autoimmune diseases to the treatment of osteoarthritis. The problem many times
is that we just do not have enough T-reg cells to go around. T-regs are not
easy to culture expand (grow them in a lab). What scientists are attempting to
do is get other immune cells which are more plentiful and convert them into
T-reg cells. This is called an induced T-reg cell
(i-T reg cell). In
another word, one type of immune cell is being coaxed to turn into a T-reg cell.
This is a newer realm in the stem cell world. The following illustration shows
Usually, when we are
dealing with induced cells we will take a skin or similar cell and treat it either
with a virus or enzyme to reprogram the cell. They are now doing this by
treating the cell with certain transcription factors. This treatment makes the
cell go back in time and act as much younger cell having the capabilities of
becoming many different types of cells. These are called induced pluripotential
stem cells or IPS cells. We see in the
above illustration that these induced cells act very similar to embryonic cells.
There is a great deal of research currently underway with these cells. The
problem with the induced T-reg cells is that they do not appear to be stable.
next portion of the article deals on how to increase the stability of the
induced T-reg cells and for that matter regular T-reg cells. This has possible
far reaching ramifications for our health. One important factor that affects
the T-reg cell stability is something called a TET protein. Actually, TET
stands for Ten-Eleven Transcription factor proteins. Transcription is the process where a gene's DNA
sequence is copied (transcribed) into an RNA molecule. Transcription is a key
step in using information from a gene to make a protein. The RNA will carry a
message and it is thus called messenger RNA (mRNA). This is the basis for many
of the Covid vaccines.
DNA contains all information that
cells in our body need to function by providing specific codes to produce
specific proteins. Not all parts of DNA are accessible in all cells at all
times. The regulated production of proteins ensures that different cells and
organs can be developed from the same DNA. Remember one cell has all the
genetic information to reproduce the whole body. What that one cell makes
depends upon how the cell is regulated. An important regulatory mechanism is
the reversible addition (methylation) or removal (demethylation) of certain chemical
bonds, so-called methyl groups, to segments of DNA. This modifies the readout
of the DNA segment. The next illustration demonstrates the concept of
methylation and how transcription works. We have now broached an important
scientific field called EPIGENETICS. Epigenetics deals with how certain genes get turned on or off. The illustration shows these concepts.
In the course of life, aging processes, environmental influences and lifestyle factors
such as smoking or diet induce biochemical alterations to the
DNA. Frequently, these lead to DNA methylation, a process in which methyl
groups (CH3) are added to particular DNA segments, without changing
the DNA sequence. This causes changes in how the DNA behaves.
Getting back to the TET Proteins, they can
decrease the production of certain proteins in immune cells. How TET proteins
play into the development of autoimmune diseases is still not completely
understood. TET transcription factors, a family of cancer
suppressive proteins, help regulate gene activity via their influence on
chromosomal architecture. TET enzymes facilitate DNA demethylation (
removal of CH3).
Methylation can change the activity of a DNA
segment without changing the sequence. When located in a gene promoter, DNA
methylation typically acts to repress gene transcription. Researchers
have linked abnormal DNA methylation to several human diseases. DNA methylation
is a commonly used epigenetic signaling tool that can fix genes in the off
position. Remember Epigenetics deals with how reversible changes in
DNA affect gene activity and protein expression. Disrupting this machinery can
have dramatic effects on cellular function and overall health.
What the article tells us is that Vitamin C has
the ability to enhance the enzymatic activity of the TET proteins. So far, the problem has been that the converted iT-reg cells did
not seem to function well. It has been very challenging to come up with the
right molecular ingredients to allow the induced cells to survive. Vitamin C
seems to change the dialog. The article discusses the symbiosis of Vitamin C and TET proteins and their
effects on T-reg cells. This technique involves the reprogramming of
effector or memory T cells into iT-regs. The bottom line is that the Vitamin C
and the TET proteins will induce a stable i-Treg cell. Hopefully, in the not
too distant future stable i-Treg cells will become a reality.
C is found to be a key mediator of the interface between genome and
environment. It regulates DNA demethylation as a cofactor for TET. It is shown
that vitamin C drives active removal of DNA methylation by enhancing TET enzymes. Thus, Vitamin C is not
just an anti-oxidant but has other powerful regulatory function. THIS IS A BIG DEAL!
Recent studies have shown that Vitamin C
potentiates the effects of DNA methyltransferase inhibitors. DNA methyltransferases are a family of writer
enzymes responsible for DNA methylation by the addition of a methyl group. Epigenetic
alterations, along with genetic mutations contribute to onset of cancer. It is
shown that Vitamin C drives active removal of DNA methylation by enhancing TET
enzymes. This helps to erase DNA methylation which allows epigenetic memory
encoded by it to improve reprogramming of differentiated cells to an embryonic-like
In the above illustration we see Vitamin C at
work. It is blocking a DNA writer. It is inhibiting the addition of the
methyl group to the DNA. Here is the proof that Vitamin C affects how our DNA
functions. The famous scientist, Linus Pauling, recommended mega doses of
Vitamin C. He was mocked for recommending large doses of Vitamin C for
preventing the common cold among other things. Ask your friends if they have
been taking large doses of Vitamin C to try to help prevent Covid. It looks
like Pauling will have the last laugh. It reminds me of a saying from Arthur
Schopenhauer Truth passes through three stages: First it is Ridiculed. Second,
it is violently opposed. Third, it is accepted as self-evident.
The take away here is Vitamin
C is an essential micronutrient and a free radical scavenger. These are well
known facts. At the same time, it has functions such as blocking oncogenic
transformation induced by carcinogens by its effects on epigenetics. The
epigenetic effects of vitamin C and its effects on the health of the immune
system far outweigh it acting as an anti-oxidant. One final thought, in our
clinic we are able to offer multiple combinations of Vitamin C via an
intravenous route. The intravenous route insures better bioavailability.Thanks, Dr P
is the link to the article: https://scitechdaily.com/vitamin-c-is-a-key-ingredient-for-immune-cell-function-a-leg-up-in-treating-autoimmune-diseases/
Sometimes the government is the last to know. The U.S.
military is about to start testing anti-aging compounds. Guess which one? Hint: It begins with an 'N', ends with a 'D' and has an 'A' in the middle. The answer is NAD.
I was recently sent an article from a friend. It was
interesting in that it was discussing the fact that the U.S. military will be
testing NAD as an anti-aging supplement and performance enhancer. I looked up
this up and found that this information was reported on a number of different
sites. I happened to pick the Popular Science article and it is included below.
The military is doing something that we have known about in the real world for
some time. NAD supplements seem to act in an anti-aging fashion and seem to
improve performance, both mentally and physically. I suspect over time they
will also discover that giving the NAD intravenously with the oral supplements
will work even better. I suspect over time they will also discover certain
tricks to make NAD absorption better, more efficient and quicker. Finally, they
will also learn that they will need to act against Senescent cells when NAD is
given or we may have the opposite effect on the patient. These are treatment
protocols that we have developed in our clinic over time. Below is the link.
Enjoy the article:https://www.popularmechanics.com/science/health/a36905562/us-military-testing-anti-aging-pill/Thanks, Dr. P